Metabolism

Paramount in importance is the continuous flow of oxygenated blood. This flow is central to metabolism, the production of energy and other materials necessary for life. Energy production is synonymous with life. No energy…no life.

Energy production through oxygenation (with oxygen) yielding 32 ATP molecules from the interaction of one glucose and one oxygen molecule. Blood delivers oxygen and glucose to the tissues. One molecule of glucose is oxidized in the cell’s mitochondria to produce 36 adenosine triphosphate molecules (ATP).

O2 + Glucose = H2O + CO2 ===> 36 ATP

Metabolism that utilizes oxygen is called aerobic metabolism. The above equation is the balance of the much abbreviated Kreb’s cycle. Any unsettled memories bubbling up? The point is that oxygen when combined with glucose produces a substantial amount of energy.

Note that ATP is the primary energy molecule for the body. Virtually every activity – thinking, movement, cardiac contraction, protein formation, etc. – requires ATP. Without a continuous production of ATP, each of these processes would cease.

When energy demands surpass the supply of vital energy precursors such as oxygen, cells are left with the much less efficient anaerobic energy production – metabolism without oxygen. An insufficient supply of oxygen can occur due to hypoxia, obstructed blood vessels, anemia or low cardiac output conditions.

Anaerobic metabolism is not an efficient energy producer.

O2 + Glucose = LACTIC ACID ===> ONLY 2 ATP

Aerobic metabolism is clearly superior to anaerobic metabolism with regards to energy production. Anaerobic metabolism yields only 2 ATP. Also the production of acid (lactic acid) can alter the acid-base balance and hamper several vital intercellular chemical reactions.

Anaerobic metabolism can buy some time for activities that occur sporadically (i.e. sprinting or weight lifting). Anaerobic metabolism does not produce enough ATP to sustain the viability of cells that are engaged in rhythmic or continuous activity (i.e. myocardial cells).

We have all experienced the effects of anaerobic metabolism after over-engaging in a strenuous activity. The next day our muscles are painful. No, not stairs! Our blood vessels simply delivered insufficient amounts of oxygen and nutrients to satisfy the needs of these muscles. The muscles turned to anaerobic metabolism to boost the ATP supply. As a result, lactic acid accumulated in our tissues.

1. Six Second ECG Guidebook (2012), T Barill, p. 25

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