Repolarization

Follows depolarization, involving the return to a pre-depolarization state; the myocardial cell’s electrical potential returns from +30 mV to its polarized state of –90 mV; the ions potassium, calcium and sodium are largely involved; note that contraction of the myocardial cell occurs during repolarization.

The QRS complex is a representation of ventricular depolarization. The repolarization of the atria is also buried in the QRS complex.

The T Wave is a graphical representation of the repolarization of the ventricles.

The T wave is typically about 0.10 to 0.25 seconds wide with an amplitude less than 5 mm. While ventricular depolarization occurs rapidly producing a tall QRS complex, ventricular repolarization is spread over a longer interval, resulting in a shorter and broader T wave.

If ventricular repolarization returns cell membrane voltage back to its predepolarization resting electrical voltage, then shouldn’t the wave produced by ventricular repolarization be opposite that of ventricular depolarization? In other words, should the QRS complex and the T wave face opposite directions, upright and inverted. This is usually not the case.

Ventricular depolarization proceeds from the endocardium to the epicardium, essentially depolarizing the ventricles from the inside out. It follows that repolarization also occurs from the inside out, producing inverted T waves opposite in direction to the QRS complex. Instead, repolarization is delayed in endocardial cells, allowing the epicardium to repolarize first. Repolarization normally proceeds opposite to depolarization, from the outside in. An upright T wave results.

An inverted T wave can point to cardiac ischemia among other causes. Ischemia to the epicardium prolongs ventricular repolarization to this area. This extended repolarization of the epicardium removes the delay between the repolarization of the endocardium and the repolarization of the epicardium, with repolarization now following the sequence of depolarization. An inverted T wave results.

Occasionally, another wave -the U wave – is recorded immediately following the T wave and before the P wave. The U wave remains rather mysterious but is thought to represent a final stage of repolarization of unique ventricular cells in the midmyocardium. The U wave will most often orient in the same direction as the T wave with an amplitude less than 2 mm.

An abnormal U wave is inverted or tall with an amplitude of 2 mm or more. An abnormally tall U wave is associated with conditions such as hypokalemia, diabetes, ventricular hypertrophy, and cardiomyopathy. Cardiac medications such as digoxin and quinidine can also cause a tall U wave.

Figure 4.13 The QRS Complex, ST Segment and the T Wave

Figure 4.13 depicts the component parts of the QRS complex. The QRS complex consists of a series of waves, the ‘Q’, ‘R’, and ‘S’ waves. The ‘Q’ wave is the first negative deflection from baseline. The ‘R’ wave is the first positive deflection above baseline. The ‘S’ wave follows the ‘R’ wave with a negative deflection. A QRS complex may or may not have all three waveforms. The ST segment begins at the J point and continues to the beginning of the T wave.

1. Six Second ECG Guidebook (2012), T Barill, p. 87, 204

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